Often the patients exhibit repetitive queries. Transient Global Amnesia (TGA) is a condition defined by the abrupt loss of short term memory while preserving autobiographic memory and in the absence of localizing signs on the neurological examination (1, 2). Because primary TGA (no lesions apparent on imaging) may represent a migraine phenomenon according to previous reports, I propose that these two patients exhibited “cough-induced TGA”, precipitated by a similar mechanism causing cough headache but presenting as pure confusional migraine, or more formally defined, as “cough-induced persistent cognitive migraine aura without stroke.” Introduction Symptoms were typical of transient global amnesia (TGA). Imaging studies failed to show structural or acute vascular lesions on either patient.
Neither of the two patients had history of migraine or epilepsy. The first patient had recurrent allergic bronchitis the second patient had hereditary pressure palsy neuropathy (HPPN) secondary to a mutation in the PMP 22 gene manifested by protracted cough, eventually ameliorated by the administration of Levetiracetam. Two patients developed acute loss of short term memory of several hours duration while preserving autobiographic memory and exhibiting no focal signs and symptoms following a crisis of severe coughing.
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